These are similar to the supravalvular aortic stenosis syndrome described in infants by Black in England (1963). No long-term animal studies have been performed to evaluate the drug's potential in these areas.Īnimal reproduction studies have shown fetal abnormalities in several species associated with hypervitaminosis D. Mineral oil interferes with the absorption of fat-soluble vitamins,including vitamin D preparations.Īdministration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with Ergocalciferol Capsules may cause hypercalcemia.Ĭarcinogenesis, Mutagenesis, Impairment of Fertility Maintenance of a normal serum phosphorus level by dietary phosphate restriction and/or administration of aluminum gels as intestinal phosphate binders in those patients with hyperphosphatemia as frequently seen in renal osteodystrophy is essential to prevent metastatic calcification.Īdequate dietary calcium is necessary for clinical response to vitamin D therapy. In the treatment of hypoparathyroidism, intravenous calcium, parathyroid hormone, and/or dihydrotachysterol may be required. When high therapeutic doses are used progress should be followed with frequent blood calcium determinations. IN VITAMIN D RESISTANT RICKETS THE RANGE BETWEEN THERAPEUTIC AND TOXIC DOSES IS NARROW. Dosage levels must be individualized and great care exercised to prevent serious toxic effects. Therapeutic dosage should be readjusted as soon as there is clinical improvement. Vitamin D administration from fortified foods, dietarysupplements, self-administered and prescription drug sources should be evaluated. In these cases vitamin D must be strictly restricted.
Hypersensitivity to vitamin D may be one etiologic factor in infants with idiopathic hypercalcemia. Inactive Ingredients: Butylated hydroxytoluene, D&C Yellow #10, FD&C Blue #1, Gelatin, Glycerin, Propylene Glycol, Shellac, Simethicone, Soybean oil and Titanium Dioxide. One USP unit of vitamin D2 is equivalent to one International Unit (IU), and 1 mcg of vitamin D2 is equal to 40 IU.Įach capsule contains 1.25 mg (50,000 International Units vitamin D) of ergocalciferol, USP, in an edible vegetable oil.Įrgocalciferol, also called vitamin D2, is 9, 10-secoergosta-5, 7, 10(19), 22-tetraen-3-ol, (3ß, 5Z, 7E, 22E)- (C28H44O) with a molecular weight of 396.65, and has the following structural formula: There are more than 10 substances belonging to a group of steroid compounds, classified as having vitamin D or antirachitic activity.
Ergosterol or provitamin D2 is found in plants and yeast and has no antirachitic activity. Ergocalciferol Capsules, USP is a synthetic calcium regulator for oral administration.Įrgocalciferol is a white, colorless crystal, insoluble in water, soluble in organic solvents, and slightly soluble in vegetable oils.
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